In 2012, Khalifa's fourth studio album, O.N.I.F.C., was preceded by the release of the singles ' Work Hard, Play Hard' and ' Remember You', which both charted in the top 75 of the Billboard Hot 100. Both of these songs reached the top 10 of the Billboard Hot 100. In 2011, Khalifa recorded many collaborations with other artists that proved to be commercially successful, including ' 5 O'Clock' with T-Pain and Lily Allen, and ' Young, Wild & Free' with Snoop Dogg. Three further singles from Rolling Papers, Billboard Singles ' Roll Up', ' On My Level' – a collaboration with fellow rapper Too Short – and ' No Sleep' also charted in the United States.

The International Hit 'Black and Yellow' appeared on Khalifa's first studio album for Atlantic (and third overall), Rolling Papers, which peaked at number two on the US Billboard 200 and was certified gold by the RIAA. The song was later certified six-times platinum by the Recording Industry Association of America (RIAA) for digital download shipments exceeding 6,000,000 copies. Khalifa's first single for the label, ' Black and Yellow', achieved significant commercial success in the United States, peaking at number one on the US Billboard Hot 100 and also peaking in the top ten of both the Canadian and United Kingdom singles charts. In April 2010, Khalifa released a mixtape, Kush & Orange Juice, which acquired widespread attention after topping Google's Hot Search Trends list: this brought Khalifa to the attention of Atlantic Records, who promptly signed him. Disagreements with Warner over the release of a purported major-label debut album led Khalifa to departed from the label, and release his second studio album Deal or No Deal in 2009 on Rostrum Records alone. The latter became his first song to appear on a Billboard chart, peaking at number 20 on the US Hot Rap Songs. At Warner, Khalifa released the singles 'Youngin' on His Grind' and ' Say Yeah'. Records signed Khalifa in 2007 as part of a joint deal with Rostrum. Following the release of Show and Prove, Warner Bros. After signing to independent record label Rostrum Records at a young age, Khalifa released his first mixtape Prince of the City: Welcome to Pistolvania, and his first studio album, Show and Prove (2006). American rapper Wiz Khalifa has released seven studio albums, one compilation album, one soundtrack album, three extended plays (EP), two collaborative albums, 84 singles (including 44 as a featured artist), sixteen promotional singles, twenty-one mixtapes, and 82 music videos.

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